abstract：:The Save Our Sisters Project builds on the roles of 95 "natural helpers" to increase mammography screening among older African American women in a NC county. Natural helpers are lay people to whom others naturally turn for advice, emotional support, and tangible aid. Findings from 14 focus group interviews showed that...

journal_title：Breast cancer research and treatment

authors： Eng E,Smith J

更新日期：1995-07-01 00:00:00

abstract：:Over the last several years, evidence has accumulated to support the idea that rare Ha-ras polymorphisms are associated with inherited susceptibility to certain human cancers. A recent epidemiologic study conducted at our institution found a significant association specifically with breast cancer, although the mechani...

journal_title：Breast cancer research and treatment

authors： Conway K,Edmiston S,Fried DB,Hulka BS,Garrett PA,Liu ET

更新日期：1995-07-01 00:00:00

abstract：:Ductal carcinoma in situ (intraductal carcinoma) of the breast is a commonly recognized and curable clinical entity. Patients with intraductal carcinoma are at risk to develop invasive breast cancer presumably due to a transition from the noninvasive to the invasive phase of growth. Primary breast malignancies commonl...

journal_title：Breast cancer research and treatment

authors： Iglehart JD,Kerns BJ,Huper G,Marks JR

更新日期：1995-06-01 00:00:00

abstract：:The effect of obesity and fat distribution on survival of breast cancer patients was studied prospectively in 241 women with a natural menopause who participated in a breast cancer screening project, the DOM-project in Utrecht, The Netherlands. Mean follow-up time was 9.1 years and endpoint of interest was death from ...

journal_title：Breast cancer research and treatment

authors： den Tonkelaar I,de Waard F,Seidell JC,Fracheboud J

更新日期：1995-05-01 00:00:00

abstract：:The association between body fat distribution and breast cancer risk was studied in 5923 pre- and 3568 post-menopausal women, participating in a breast cancer screening project (the DOM-project in Utrecht, the Netherlands). Cases were fifty six premenopausal women and thirty eight postmenopausal women with breast canc...

journal_title：Breast cancer research and treatment

authors： den Tonkelaar I,Seidell JC,Collette HJ

更新日期：1995-04-01 00:00:00

abstract：:MCF-7 cells, a metastatic human breast carcinoma line, caused dose-dependent platelet aggregation in heparinized human platelet-rich plasma (PRP). MCF-7 tumor cell-induced platelet aggregation (TCIPA) was almost blocked by apyrase (0.5 U/ml) and completely inhibited by hirudin (5 U/ml). This TCIPA was unaffected by cy...

journal_title：Breast cancer research and treatment

authors： Chiang HS,Swaim MW,Huang TF

更新日期：1995-03-01 00:00:00

abstract：:In 1973, McGuire and Chamness (In: O'Malley BW and Means AR (ed) Receptors for Reproductive Hormones, Plenum Press) summarized their work on the estrogen receptor in animal and human breast tumors, and in so doing described a target for therapeutic intervention. At that time there were no clinically useful antiestroge...

journal_title：Breast cancer research and treatment

authors： Jordan VC

更新日期：1995-01-01 00:00:00

abstract：:Paclitaxel is a highly active single agent as therapy for previously untreated as well as doxorubicin-refractory metastatic breast cancer, with associated response rates of 62% and 20-48%, respectively. Complete responses with paclitaxel occur chiefly in breast cancer patients whose metastatic disease has not been pre...

journal_title：Breast cancer research and treatment

authors： O'Shaughnessy JA,Cowan KH

更新日期：1995-01-01 00:00:00

abstract：:One in six primary human breast cancers has DNA amplification centered on the cyclin D1 gene (CCND1) on chromosome 11q13. This genetic abnormality is preferentially associated with estrogen-receptor positive tumors and may define a sub-class of patients with an adverse prognosis. Although CCND1 has the credentials of ...

journal_title：Breast cancer research and treatment

authors： Peters G,Fantl V,Smith R,Brookes S,Dickson C

更新日期：1995-01-01 00:00:00

abstract：:The diagnosis and treatment of patients with breast cancer is beginning to be influenced by new ideas and discoveries emerging from the field of angiogenesis research. This field, pursued in the laboratory for more than 20 years, has in the past 5 years generated clinical applications. Some of these applications have ...

journal_title：Breast cancer research and treatment

authors： Folkman J

更新日期：1995-01-01 00:00:00

abstract：:The ability of the antiangiogenic agents TNP-470 and minocycline, singly or in combination, to potentiate the antitumor effects of several cytotoxic therapies was assessed in the murine EMT-6 mammary carcinoma as well as in two drug resistant sublines of that tumor designated EMT-6/CTX and EMT-6/CDDP. The antiangiogen...

journal_title：Breast cancer research and treatment

authors： Teicher BA,Holden SA,Dupuis NP,Kakeji Y,Ikebe M,Emi Y,Goff D

更新日期：1995-01-01 00:00:00

abstract：:Feulgen-stained samples from 460 small (pT1) primary breast cancers were investigated by means of an image analysis system. Several DNA, morphometrical and textural parameters were evaluated for each patient, and the prognostic meaning of these parameters was then investigated by the Cox regression analysis. As progno...

journal_title：Breast cancer research and treatment

authors： Aubele M,Auer G,Falkmer U,Voss A,Rodenacker K,Rutquist LE,Höfler H

更新日期：1995-01-01 00:00:00

abstract：:Metastasizing cancer cells can invade the extracellular matrix using plasma membrane protrusions, termed invadopodia, that contact and dissolve the matrix. Various membrane associated proteases localized on the invadopodial membranes are responsible for the extracellular matrix degradation. Work from our laboratory sh...

journal_title：Breast cancer research and treatment

authors： Chen WT,Lee CC,Goldstein L,Bernier S,Liu CH,Lin CY,Yeh Y,Monsky WL,Kelly T,Dai M

更新日期：1994-01-01 00:00:00

abstract：:This review will focus on the role of sphingosine and its phosphorylated derivative sphingosine-1-phosphate (SPP) in cell growth regulation and signal transduction. We will show that many of the effects attributed to sphingosine in quiescent Swiss 3T3 fibroblasts are mediated via its conversion to SPP. We propose that...

journal_title：Breast cancer research and treatment

authors： Spiegel S,Olivera A,Zhang H,Thompson EW,Su Y,Berger A

更新日期：1994-01-01 00:00:00

abstract：:Neural networks can be used as pattern recognition systems in complex data sets. We are exploring their utility in performing survival analysis to predict time to relapse or death. This technique has the potential to find easily some types of very complex interactions in data that would not be easily recognized by con...

journal_title：Breast cancer research and treatment

authors： De Laurentiis M,Ravdin PM

更新日期：1994-01-01 00:00:00

abstract：:Immunotoxins are a relatively new class of cytotoxic agents consisting of a catalytic toxin linked to an appropriate targeting ligand. The ligand directs the toxin to the surface of a tumor cell, whereupon the toxin enters the cell and catalytically inactivates the ribosome, thus disrupting protein synthesis and effec...

journal_title：Breast cancer research and treatment

authors： LeMaistre CF,Meneghetti C,Howes L,Osborne CK

更新日期：1994-01-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is expressed in benign and malignant breast epithelium. The EGFR, when mutated or over-expressed in the presence of its ligand, is transforming in other tissues or cell types. It is therefore of major interest in the pathogenesis of human breast cancer to understand the role...

journal_title：Breast cancer research and treatment

authors： Harris AL

更新日期：1994-01-01 00:00:00

abstract：:Estrogen has an important role in stimulating the growth of breast carcinomas. Inhibition of estrogen production is therefore a logical treatment strategy. A number of selective inhibitors have been developed against aromatase, a cytochrome P-450 enzyme which catalyzes the rate limiting step in the biosynthesis of est...

journal_title：Breast cancer research and treatment

authors： Brodie AM,Santen RJ

更新日期：1994-01-01 00:00:00

abstract：:A number of endocrine treatments for advanced breast cancer seem to affect serum insulin-like growth factor I (IGF-I). The aim of our study was to investigate IGF-I levels in 33 postmenopausal patients with metastatic disease receiving the selective aromatase inhibitor 4-hydroxyandrostenedione: 250 mg (16 patients) or...

journal_title：Breast cancer research and treatment

authors： Ferrari L,Zilembo N,Bajetta E,Buzzoni R,Noberasco C,Martinetti A,Celio L,Galante E,Orefice S,Cerrotta AM

更新日期：1994-01-01 00:00:00

abstract：:The relationships between urinary 11-desoxy-17-oxo steroids (11-DOS), the ratio of 11-DOS to urinary 17-hydroxycorticosteroids (urinary discriminant ratio), plasma levels of the adrenal androgens dehydroepiandrosterone (DHA), DHA sulphate (DHAS), and 7 alpha-hydroxy DHA (7 alpha DHA), and tumour oestrogen receptor (ER...

journal_title：Breast cancer research and treatment

authors： Mason BH,Holdaway IM,Skinner SJ,Kay RG

更新日期：1994-01-01 00:00:00

abstract：:The prognostic value of epidermal growth factor receptor (EGF-R) was prospectively assessed in a series of 229 clinical T1-T2, N0-N1 breast carcinomas diagnosed between May 1987 and October 1989. EGF-R expression was determined by measuring the specific Bmax of 125I EGF to tumor plasma membrane preparations. Tumor wit...

journal_title：Breast cancer research and treatment

authors： Bolla M,Chedin M,Colonna M,Marron-Charrière J,Rostaing-Puissant B,Pasquier D,Panh MH,Winckel P,Chambaz EM

更新日期：1994-01-01 00:00:00

abstract：:Sustained breast cancer growth and metastasis requires paracrine signals between the tumor cells and the normal surrounding host tissue. One crucial function of these signals is to recruit endothelial cells and thus new blood vessels for the nourishment of the expanding tumor mass. This proliferation and migration of ...

journal_title：Breast cancer research and treatment

authors： Wellstein A

更新日期：1994-01-01 00:00:00

abstract：:Tamoxifen citrate is a synthetic antiestrogen that provides survival benefit when given as adjuvant treatment in postmenopausal women with breast cancer. Venous thrombophlebitis may complicate tamoxifen treatment at a rate of approximately one per 800 treatment-years. To explore the possible procoagulant effects assoc...

journal_title：Breast cancer research and treatment

authors： Mamby CC,Love RR,Feyzi JM

更新日期：1994-01-01 00:00:00

abstract：:Droloxifene, a new antiestrogen, has theoretical advantages over tamoxifen based on preclinical data. These include higher affinity to the estrogen receptor, higher antiestrogenic to estrogenic ratio, and more effective inhibition of cell growth and division in ER positive cell lines, as well as less toxicity, includi...

journal_title：Breast cancer research and treatment

authors： Rauschning W,Pritchard KI

更新日期：1994-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFr) levels were analyzed in 140 primary breast cancer specimens by immunohistochemical assay (ICA), competitive binding assay (BA), or enzyme immunoassay (EIA). Thirty-nine of 118 specimens (33.1%) were scored as positive by ICA, 30 of 116 (25.9%; cut-off level 10 fmol/mg protein) b...

journal_title：Breast cancer research and treatment

authors： Iwase H,Kobayashi S,Itoh Y,Kuzushima T,Yamashita H,Iwata H,Naito A,Yamashita T,Itoh K,Masaoka A

更新日期：1993-12-01 00:00:00

abstract：:The use of exogenous sex-steroids for hormonal contraception is important to the way of life of many modern women. The widespread use of hormonal contraceptives represents a unique opportunity to have a substantial positive impact on women's health. The observation that users of oral combination type contraceptives ha...

journal_title：Breast cancer research and treatment

authors： Spicer DV,Pike MC

更新日期：1993-11-01 00:00:00

abstract：:This is the consensus statement regarding the clinical utility of DNA cytometry in breast cancer from the DNA Cytometry Consensus Conference held in Prout's Neck, Maine, USA, on October 1-4, 1992. Guidelines for clinical DNA cytometry generated at that meeting also appear in this issue of Breast Cancer Research and Tr...

journal_title：Breast cancer research and treatment

authors： Hedley DW,Clark GM,Cornelisse CJ,Killander D,Kute T,Merkel D

更新日期：1993-10-01 00:00:00

abstract：:A detailed analysis of the immune system response has been performed during the development and progression of dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors. For this aim, a number of immune parameters (thymocyte and splenocyte proliferative response to T-dependent mitogens, antibody production, lymphocy...

journal_title：Breast cancer research and treatment

authors： Gallo F,Morale MC,Sambataro D,Farinella Z,Scapagnini U,Marchetti B

更新日期：1993-09-01 00:00:00

abstract：:The mechanism of action of the pure antiestrogens ICI 164384 and ICI 182780 has been investigated. Both antagonists are steroidal antiestrogens with 7 alpha-alkylamide side-chains. The antiestrogens reduce the cellular content of the estrogen receptor by reducing the half-life of the protein. A potential mechanism for...

journal_title：Breast cancer research and treatment

authors： Parker MG

更新日期：1993-01-01 00:00:00

abstract：:To better define the influence by host factors on very early breast cancer behavior, we retrospectively analyzed nodal status, diameter of the largest axillary metastasis (M), diameter of the primary tumor (P), the M/P ratio, tumor estrogen receptor status, age, obesity, and smoking habits in 176 women with node-posit...

journal_title：Breast cancer research and treatment

authors： Daniell HW,Tam E,Filice A

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:We have developed a decision analysis model that uses the results of available randomized controlled trials to model the natural history of early breast cancer and assess the potential clinical and financial effects of using adjuvant therapies. PATIENTS AND METHODS:The original model was used to assess the ...

journal_title：Breast cancer research and treatment

authors： Hillner BE,Smith TJ,Desch CE

更新日期：1993-01-01 00:00:00

abstract：:We characterized the structure and the function of insulin receptors isolated from 10 human breast cancer specimens. We observed that the insulin receptor content, as determined by a specific radioimmunoassay, was four fold increased in human breast cancer tissue when compared to normal breast tissues. In both cancer ...

journal_title：Breast cancer research and treatment

authors： Frittitta L,Vigneri R,Papa V,Goldfine ID,Grasso G,Trischitta V

更新日期：1993-01-01 00:00:00

abstract：:Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient m...

journal_title：Breast cancer research and treatment

authors： Brünner N,Boysen B,Rømer J,Spang-Thomsen M

更新日期：1993-01-01 00:00:00

abstract：:The aromatase inhibitor 10-propargylestr-4-ene-3,17-dione (PED) has been evaluated in vivo as an anticancer agent. Prolonged administration of PED to rats bearing dimethylbenzanthracene-induced mammary tumors resulted in significant regression of hormone-responsive tumors within several days. Greater than 50% regressi...

journal_title：Breast cancer research and treatment

authors： Zimniski SJ,Brandt ME,Covey DF,Puett D

更新日期：1993-01-01 00:00:00

abstract：:We have evaluated tandem cycles of a tri-drug combination, termed CVP (cyclophosphamide, etoposide [VP-16], and cisplatin [Platinol]), at four levels in more than 300 patients with various types of tumors. Tandem CVP appears to be at least therapeutically equivalent to alternatives. A second potentially non-cross-resi...

journal_title：Breast cancer research and treatment

authors： Spitzer G,Adkins D,Dunphy F,Petruska P,Spencer V,Velasquez W

更新日期：1993-01-01 00:00:00

abstract：:Medroxyprogesterone acetate (MPA) is well recognized to have beneficial effects for the treatment of advanced breast cancer which are comparable to those achieved with other forms of endocrine therapy. Using mammary tumors induced in the rat by dimethylbenz(a)anthracene (DMBA) as a model, we have studied the possibili...

journal_title：Breast cancer research and treatment

authors： Labrie F,Li S,Bélanger A,Côté J,Mérand Y,Lepage M

更新日期：1993-01-01 00:00:00

abstract：:Over the past two decades, the simple model for control of breast cancer growth involving one or two factors acting directly or indirectly via endocrine pathways has turned into a complex model implicating numerous interacting factors and the diverse cell populations constituting breast tumors. Current approaches to b...

journal_title：Breast cancer research and treatment

authors： Freiss G,Prébois C,Vignon F

更新日期：1993-01-01 00:00:00

abstract：:The epidermal growth factor (EGF) is one of several growth factors involved in normal breast epithelial development and tumor proliferation. EGF and EGF-like peptide TGF alpha bind and activate the same membrane receptor protein. This receptor (EGF-R) has been recently studied in breast tumor biopsies and its detectab...

journal_title：Breast cancer research and treatment

authors： Falette N,Lefebvre MF,Meggouh F,Eynard M,Garin E,Saez S

更新日期：1992-03-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) are mitogens for many cancer cell types. In breast cancer cells, IGF-I and IGF-II have both been shown to stimulate cell proliferation. However, IGF-I mRNA has not been found in human breast cancer cell lines, making it unlikely that IGF-I is commonly expressed as an autocrine gr...

journal_title：Breast cancer research and treatment

authors： Cullen KJ,Allison A,Martire I,Ellis M,Singer C

更新日期：1992-01-01 00:00:00

abstract：:Breast cancer is heavily influenced by the reproductive history of the individual. Pregnancy has a protective effect which is attributed to differences in the degree of differentiation of the breast. The purpose of this work was to determine whether the quantity and the type of parenchymal structures present in the hu...

journal_title：Breast cancer research and treatment

authors： Russo J,Rivera R,Russo IH

更新日期：1992-01-01 00:00:00